Determination of flavonoids from Perilla frutescens var. japonica seeds and their inhibitory effect on aldose reductase
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چکیده
منابع مشابه
Rapid Identification of Aldose Reductase Inhibitory Compounds from Perilla frutescens
The ethyl acetate (EtOAc) soluble fraction of methanol extracts of Perilla frutescens (P. frutescens) inhibits aldose reductase (AR), the key enzyme in the polyol pathway. Our investigation of inhibitory compounds from the EtOAc soluble fraction of P. frutescens was followed by identification of the inhibitory compounds by a combination of HPLC microfractionation and a 96-well enzyme assay. Thi...
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Allergy is characterized by an overreaction of the immune system. Perilla frutescens leaf extract has been reported to exhibit antiallergic inflammatory activity. To investigate precisely the effect and mechanism of 30% ethanol extract powder of P. frutescens var. acuta Kudo (EPPF) and rosmarinic acid (RA), a component of EPPF in allergic rhinitis and rhinoconjunctivitis, the antiallergic effec...
متن کاملinhibitory activity of flavonoids on the lens aldose reductase of healthy and diabetic rats
aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses. in this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. thirty m...
متن کاملInhibitory Activity of Flavonoids on the Lens Aldose Reductase of Healthy and Diabetic Rats
Aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. Inhibition of the activity of this enzyme can prevent cataract in diabetic patients’ lenses. In this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. Thirty ...
متن کاملGrowth inhibitory and apoptosis inducing effect of Perilla frutescens extract on human hepatoma HepG2 cells.
Perilla frutescens (L.) Britt. (Lamiaceae) has traditionally been used to treat diseases, including tumors, but the antitumorigenesis mechanism is unclear. We evaluated the effects of Perilla frutescens leaf extract (PLE) on proliferation and apoptosis inducing in human hepatoma HepG2 cells using a cell proliferation assay, flow cytometry, and cDNA microarrays. Gene expression and apoptosis wer...
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ژورنال
عنوان ژورنال: Applied Biological Chemistry
سال: 2017
ISSN: 2468-0834,2468-0842
DOI: 10.1007/s13765-017-0260-5